Mrs. Guadagno is a witch-turned-mortal who lives in Rome. She is introduced in the TV movie "Sabrina Goes to Rome."


Mrs. Guadagno's family was once a family of witches but they were stripped of their magic and cast out of the Other Realm sometime in the past. She, however, hopes that one day, they will be able to gain their magic back. Mrs. Guadagno runs a hotel in Rome which offers room and board to witches when they visit the "eternal city."

She has a handome son named Alberto who she wishes to court Sabrina Spellman. However, he falls for her clumsy friend Gwen.

After Sabrina is discovered and betrayed by Paul, Mrs. Guadagno urges her to transform him to stone so she won't be stripped of her magic and cast out.